Ancillary Studies

This grant, funded by the Breast Cancer Research Program of the Department of Defense, supported a Breast Cancer Center of Excellence examining factors contributing to disparities in receipt of adjuvant therapy, and consequences for prognosis and breast cancer care. Participants were recruited from the Pathways Study, New York-area hospitals, and the Henry Ford Health Systems in Detroit, MI. This study is also referred to as the B-QUAL Study.

Funded by the American Cancer Society, the objectives of this grant are to examine the predictors and sequelae of breast-cancer-related lymphedema and its severity. This is an ancillary study with additional data collection from Pathways Study participants.

This grant, funded by the National Cancer Institute, is examining functional status and its relation to chemotherapy administration, effectiveness, and toxicity. Participants are recruited from the Pathways Study and Columbia Presbyterian Medical Center in New York.

This American Cancer Society Grant enabled analyses on adjuvant hormone therapy adherence, discontinuation, and survival.

This grant, funded by the California Breast Cancer Research Program, investigated variations in CYP2D6 and related metabolism genes modulate effectiveness of tamoxifen in participants from the Pathways Study and other studies.

This grant examined PAM50 molecular profiles in breast cancer, with participants from both the Pathways Study and Life After Cancer Epidemiology (LACE) Stuy.

This project addresses whether breast density is associated with all or only some breast cancer subtypes, and whether density influences breast cancer prognosis and predicts response to hormonal therapy in a subset of LACE and Pathways participants included in the LACE competitive renewal.

This project investigates the impact of modifiable lifestyle factors, germline genetic variations, and serum biomarkers on adverse skeletal outcomes among aromatase inhibitor (AI) users in the Pathways Study, as well as develops a prediction model for risk of fractures for postmenopausal breast cancer patients taking AIs.

This grant aims to identify breast cancer susceptibility genetic loci in Latina women. The Pathways Study will contribute to replication of the top 1,000 candidate genes discovered in other populations from whole-exome and targeted sequencing and expression analysis in germline and somatic DNA.

This ARRA Grand Opportunity grant enabled assay of inflammatory and other biomarkers, and targeted genotyping, among Pathways Study participants who had been enrolled and contributed biospecimens at the time of assay.

This grant supported germline genome-wide assays through the NIH Center for Inherited Disease Research program, and was supported as a companion grant to U01 CA195565. Genotyping was conducted using the Illumina Multi-Ethnic Global Array, with additional custom content related to breast cancer from the Vanderbilt University Biobank (BioVU), for over 1.8 million genotyped SNPs. Genotype data are available through dbGaP (phs001534.v1.p1).

This grant examines risks of cardiovascular disease risk factors and outcomes in the Pathways Study cohort, with comparisons to CVD risk in a non-breast cancer cohort from KPNC.

This grant examines associations between body size and chemotherapy dosing in breast cancer cases from KPNC and KP Washington. This grant was initially awarded as R01 CA222793.

The project examines social network factors by race and treatment status, and social network effects on treatment and outcomes after breast cancer.

Within the Pathways cohort, we project examined associations with racial/ethnic discrimination, quality of life (QoL) and residential segregation.

This is an administrative supplement to the Pathways Heart Study, studying neighborhood factors and CVD outcomes.

This grant is investigating immigrant status, social networks, and neighborhood characteristics in breast cancer outcomes in three prospective cohorts, including participants from the Pathways Study, the LACE Study, and the CHI Study.

This study leverages the Pathways Study and novel machine learning methods to assess allostatic load from EHRs records, explore whether neighborhood factors impact survivorship outcomes through a stress pathway.

This grant examines plant-based dietary patterns and dietary inflammatory indices in relation to breast cancer outcomes in the Pathways Study.

This study is investigating multilevel factors (tumor genetics, treatment adherence, health behaviors and neighborhood factors) in relation to overall and breast cancer-specific mortality across several studies with Asian American breast cancer cases, including the Pathways Study.

This study is investigating whether breast adipose tissue inflammation is associated with breast cancer outcomes, using Pathways Study surgical specimens.

This study is examining the use of dietary supplements and its effects on chemotherapy. (Not previously provided in this list).

This study is developing and testing an EHR-based algorithm to identify women with high risk of low social support, among those diagnosed with breast cancer; the Pathways Study will be a validation cohort.

This study is examining expression of proteins in the mTOR signaling pathway in tumor tissue on breast cancer prognosis, using TMAs created under Pathways Study infrastructure funding. This grant was initially awarded as R01 CA248371.

This study will develop a dietary inflammatory index for breast cancer patients based on existing Pathways Study data, and will examine associations of the index with breast cancer outcomes. Based on the index, a brief inflammatory dietary screener will be developed and tested in breast cancer patients.

This study is examining tumor DNA methylation characteristics in African American women diagnosed with breast cancer, including participants from the Women's Circle of Health and Black Women's Cohort Studies, as well as the Pathways Study. Tumor DNA methylation assays have been conducted by CIDR.

This project is investigating whether breast tumor immune profiles differ between American women with genetic similarity to African populations (AA) differ from those with genetic similarity to European populations (EA), and whether these differences are associated with risk factors, tumor aggressiveness, and survival. Contributing studies include the Women's Circle of Health Study and the Pathways Study.

This study is examining whether long noncoding RNA, a novel class of regulatory molecules, may be associated with tumor aggressiveness in African American women. Contributing studies include the Women's Circle of Health Study and the Pathways Study.

The NCI Confluence Project is assembling the largest and most diverse study of genetics and breast cancer risk and prognosis, bringing together data and biospecimens for new genotyping if necessary, from numerous studies, including the Pathways Study.

LAGENO-BC is a consortium of research studies conducted in the US and countries in Central America and South America to examine genetic factors in breast cancer risk and prognosis. The Pathways Study is contributing data related to our Latina participants. LAGENO-BC is also participating in the NCI Confluence Project.